Spinal metastatic patient who underwent palliative Palliative decompressive TL level spinal metastatic surgery Spinal metastasis, tranexamic acid,
Conditions
Interventions
apply Starsil(hemostatic agent) that it is white powder mixed 1 g of vancomycin then inject tranexamic acid that it is 20 ml of volume into surgical wound ,apply 1 g of vancomycin into surgical wound
Active Comparator Drug,Placebo Comparator Drug
Tranexamic acid with Starsil,Placebo
Sponsors
Medical Research Funding Chiang Mai University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Palliative decompressive TL level spinal metastatic surgery
Exclusion criteria
Exclusion criteria: -tranexamic acid allergy -Osteoporosis -Hb < 12 in female, <13 in male -CKD stage V, Cr > 2 mg/dL -patient who has history of thromboembolic events: ischemic stroke, ischemic heart disease, deep vein thrombosis -patient who has coagulopathy and/or bleeding tendency -patient who has ASA class IV or more according to American Society of Anesthesiologist
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| total post-operative blood loss 24 hours after surgery Unpaired T-test | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood transfusion 3 days after surgery Unpaired T-test,Complications until discharge Multivairable regression analysis | — |
Countries
Thailand
Contacts
Public ContactPermppon Somboonjai
Faculty of Medicine, Chiang Mai University
Outcome results
None listed