Male androgenetic alopecia (Hamilton-Norwood classification IIIvertex-V) Finasteride Dutasteride Male androgenetic alopecia Low-dose dutasteride Hair count Hair density Hair diameter Videodermoscopy Global photography
Conditions
Interventions
dutasteride (0.5 mg) 2 tab/week,dutasteride (0.5 mg) 3 tab/week,finasteride (1 mg) 1 tab/day
Active Comparator Drug,Active Comparator Drug,Active Comparator Drug
dutasteride 1 mg/week,dutasteride 1.5 mg/week,finasteride 1 mg/day
Sponsors
Faculty of Medicine, Srinakharinwirot University
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Male androgenetic alopecia 2. Age greater than or equal to 18 years old 3. Hamilton-Norwood classification (IIIvertex-V) 4. Able to follow-up 5. Willing to attend the project and sign informed consent form
Exclusion criteria
Exclusion criteria: 1. Past history of renal disease, hepatic disease, heart failure, benign prostatic hyperplasia 2. Past history of breast cancer or prostate cancer 3. Family history of breast cancer or prostate cancer (1st-degree relatives) 4. Past history of depressive disorder or suicidal attempt or 2Q and 9Q screening for depression scores greater than or equal to 7 5. Allergic to 5-alpha-reductase inhibitors and inactive ingredients 6. History of topical medications which affecting hair growth within 3 months prior eg. minoxidil, topical finasteride 7. History of oral medications which affecting hair growth within 6 months prior ex. dutasteride (dose greater than 1.5 mg per week), finasteride, spironolactone, ketoconazole, cyclosporine, diazoxide, cimetidine, vasodilators, steroids, chemotherapeutic agents, and antiepileptic drugs 8. History of shampoos or scalp serums which affecting hair growth within 1 month prior eg. ketoconazole shampoo 9. History of taking medicines that can cause drug interactions with medicines in this study eg. rifampicin, carbamazepine, itraconazole 10. Past history of other hair loss treatments within 3 months prior ex. low-level laser/light therapy or platelet-rich plasma 11. Past history of hair transplant 12. Have underlying disease that cause hair loss eg. anemia, hypothyroid or hyperthyroidism, diabetes mellitus, chronic alcoholism, and maldigestion/malabsorption 13. Psychiatric disorder, including trichotillomania 14. Eating disorder or restricted diet 15. Other scalp disease ex. psoriasis, seborrheic dermatitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hair count at 6 months by Folliscope | — |
Secondary
| Measure | Time frame |
|---|---|
| hair diameter at 6 months by Folliscope,hair density at 6 months by 7 point rating scale from global photography assessment,safety at 6 months questionnaire interview | — |
Countries
Thailand
Contacts
Public ContactVaralee Sereepanpanich
Faculty of Medicine, Srinakharinwirot University
Outcome results
None listed