True severe symptomatic hyponatremia patients (Serum sodium less than 125 mmol/L) severe hyponatremia, symptomatic hyponatremia, desmopressin, osmotic demyelination syndrome, overcorrection, re-lowering
Conditions
Interventions
Patients in this group treated with 3% sodium chloride solution and early desmopressin,Patients in this group treated with 3% sodium chloride solution. Desmopressin used only if re-lowering treatment
Experimental Drug,Active Comparator Drug
Proactive group,Reactive group
Sponsors
Bhumibol Adulyadej Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients age more than 18 years old 2. Confirm diagnosed for true hyponatremia (Serum sodium less than 125 mmol/L) 3. Patients with any symptoms result from hyponatremia (nausea, vomit, seizure, coma)
Exclusion criteria
Exclusion criteria: 1. Patients with hypotension 2. Patients with anuria 3. Patients with chronic kidney disease stage 4-5 4. Patients with volume overload (decompensated liver cirrhosis, congestive heart failure) 5. Patients with history pf cardiac surgery, sustained ventricular tachycardia, ventricular fibrillation, acute coronary syndrome, cerebrovascular trauma, and increased intracranial pressure within 3 months prior randomization. 6. Pregnancy or breastfeeding 7. Patients with history of desmopressin allergy. 8. Patients with current desmopressin use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of overcorrection 1, 6, 12, 18, 24, 30, 36, 42, 48 hours after treatment case number | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of hospital stay, Re-lowering rate, ODS incidence, mortality rate 28 days case number | — |
Countries
Thailand
Contacts
Public ContactNichanone Kanjanasupak
Bhumibol Adulyadej Hospital
Outcome results
None listed