septic shock patient requiring norepinephrine Mortality, Septic shock, initiation norepinephrine, Time, Norepinephrine
Conditions
Interventions
initial norepinephrine within 60 minute,initial norepinephrine more than 60 minute
Treatment,Treatment
early norepinephrine ,late norepinephrine
Sponsors
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Adult patients aged 18 years or older diagnosed with septic shock were included. The septic shock was defined by patients with suspected infection (documented or probable) who had Ramathibodi Early Warning Score (REWS) equal or more than 2, includingMAP less than 65 mm Hg and required norepinephrine infusion within 24 hours following the hypotensive event
Exclusion criteria
Exclusion criteria: patients who had a hemorrhagic shock, cardiogenic shock, end-of-life care, and patients who were delayed antibiotic more than 1 hour, received other vasopressor drugs prior to norepinephrine, changed in diagnosis within 24 hours, pregnancy, and were referred to another hospital. Patients who signed to decline or discontinue the study were also excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day all cause mortality 28 day after admission discharge summary | — |
Secondary
| Measure | Time frame |
|---|---|
| ventilator free day 28 day after admission discharge summary outcome record,The time to achieve MAP 65 mm Hg 28 day after admission discharge summary outcome record,net fluid balance 24, 48, 72 hour discharge summary outcome record,lactate clearance 24, 48, 72 hour discharge summary record outcome | — |
Countries
Thailand
Contacts
Public ContactRathakorn Thongkong
Faculty of Medicine, Mahidol university
Outcome results
None listed