Clinical motor response in Parkinson'
Conditions
Interventions
Experimental: Eradication therapy Patients who were positive for H. pylori infection are included into an eradication therapy protocol which includes oral amoxicillin 2,000 mg/day, oral clarithromycin
Concomitant HP eradication therapy,Change of pattern stool microbiome
Sponsors
Ramathibodi Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Diagnosis of Idiopathic Parkinson disease (PD) by a neurologist Written informed and consent given either by the patient or next of kin Stable Parkinson disease with demonstrable medication efficacy (at least 90 days for L-DOPA therapy, 30 days for Dopamine agonist)
Exclusion criteria
Exclusion criteria: Patients with other concomitant active neurological diseases Patients with dysphagia History of previous brain surgery for Parkinson's disease History of recent antibiotics use, proton pump inhibitors (PPIs), histamine (H2) antagonist use for at least one month prior to stool antigen test History of previous eradication therapy for Helicobacter pylori infection History of a previous gastric or duodenal cancer History of a previous gastric or major abdominal/pelvic surgery Allergy or sensitivity of proton pump inhibitor, amoxicillin, metronidazole or clarithromycin History of recent oral medication such as warfarin, and amiodarone (drug interaction with treatment protocol)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical motor response at 2 months from baseline Thai version MDS-UDPRS part III score | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical motor response at 9 months from baseline Thai version MDS-UDPRS part III score,GI symptoms at 9 months from baseline GIDS-PD,Activities of daily living scale at 9 months from baseline SE-ADL,Quality of life at 9 months from baseline PHQ-8,Non-motor symptoms at 9 months from baseline MDS-UPDRS-I, Clinical Global impression scale at 9 months from baseline CGI,Wearing-off questionnaire-9 at 9 months from baseline Thai version WOQ-9,Prevalence of a positive stool HP antigen test in Parkinson disease at first visit Prevalence,Pattern of stool microbiome in Parkinson disease before and after HP eradication therapy before and after intervention 16S rDNA gene sequencing | — |
Countries
Thailand
Contacts
Public ContactWannisa Wongpipathpong
Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol university
Outcome results
None listed