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A Comparison of Prophylactic Phenylephrine Administration between 50 and 100 mcg IV Slow Injection and Placeblo on Hypotension, Bradycardia and Other Side Effects after Spinal Anesthesia in Hypertensive Disorders of Pregnancy (HDP) during Cesarean Section : A Randomized, Single-Blind Study

A Comparison of Prophylactic Phenylephrine Administration between 50 and 100 mcg IV Slow Injection and Placeblo on Hypotension, Bradycardia and Other Side Effects after Spinal Anesthesia in Hypertensive Disorders of Pregnancy (HDP) during Cesarean Section : A Randomized, Single-Blind Study

Status
Unknown
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20221028001
Enrollment
300
Registered
2022-10-28
Start date
2022-12-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertensive disorder of pregnancy (HDP) prophylactic, phenylephrine, hypotension, HDP, cesarean section

Interventions

Phenylephrine 50 mcg IV slow injection within 15 seconds with opening three ways of 3-way stopcock to imitate the function of a syringe pump. ,Phenylephrine 100 mcg IV slow injection within 30 seconds
Experimental Drug,Experimental Drug,Sham Comparator Drug
P50,P100,Placebo

Sponsors

None listed

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. ASA physical status II or III 2. age more than or equal 18 years 3. singleton pregnany 4. Term pregnancy(GA more than or equal 37 weeks)

Exclusion criteria

Exclusion criteria: 1. cerebrovascular disease 2. complicated pregnancy (eg. placenta previa, abruptio placantae) 3. major fetal anomalies 4. history of monoamine oxidase inhibitor (MAOI) use 5. other drugs administration before baby delivery

Design outcomes

Primary

MeasureTime frame
Hypotension before baby delivery case record form—

Secondary

MeasureTime frame
Bradycardia before baby delivery case record form—

Countries

Thailand

Contacts

Public ContactRatikorn Anusorntanawat

Chaophrayayommarat hospital

netanesth@hotmail.com0819424915

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026