Patient who undergoes gynecologic laparoscopic surgery Gynecologic laparoscopic surgery Postoperative nausea vomiting Low-dose olanzapine
Conditions
Interventions
olanzapine (5mg ) 1-1.5 hrs before laparoscopic gynecologic surgery,placebo drug 1-1.5 hrs before laparoscopic gynecologic surgery
Experimental Drug,Placebo Comparator Drug
low-dose olanzapine,placebo drug
Sponsors
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patient who undergoes elective gynecologic laparoscopic surgery 2. The American Society of Anesthesiologists (ASA) Physical Status Classification I-III 3. Patient with age between 18-65 4.Patient who accept to be included in the project.
Exclusion criteria
Exclusion criteria: 1. Patient who have psychological symptoms. 2. Patient with pregnancy and breast feeding 3. Patient with morbid obesity 4. Patient with abnormal EKG (QT prolong ,Torsades de pointes) 5. Patient who have contraindication of olanzapine (drug allergy,parkinson disease,dementia) 6. Patient with severe metabolic disease 7. Patient who have indication for nasogastric tube after surgery 8. Patient with history of chemotherapy within 4 weeks before surgery 9. Patient who refuse to be included in the project.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative nausea/vomiting 24 hours postoperatively Verbal rating scale of nausea (VRS of nausea) | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative nausea/vomiting post-dose at 0,6,12,24 hours Verbal rating scale of nausea (VRS of nausea),Mean blood pressure,heart rate post-dose at 0,6,12,24 hours Mean blood pressure,heart rate,opioid medication post-dose at 0,6,12,24 hours Total amount of opioid medication patient received,Rescue anti-emetic drugs post-dose at 0,6,12,24 hours Total amount of anti-emetic medication patient received,vomiting events post-dose at 0,6,12,24 hours Total amount of vomiting events,analgesic medication post-dose at 0,6,12,24 hours Total amount of analgesic medication,sedation scores post-dose at 0,6,12,24 hours sedation scores,PACU length of stay mins Total time PACU length of stay | — |
Countries
Thailand
Contacts
Public ContactRattaphol Seangrung
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Outcome results
None listed