Cancer patients aged more than 18 years who received EGFR inhibitors therapy and have more than two paronychia/pyogenic granuloma of finger/nail that affect their everyday life. EGFR inhibitor, PRIDE syndrome, paronychia/pyogenic granuloma
Conditions
Interventions
Apply nail gutter with topical 0.5% timolol bid,Apply only topical 0.5% timolol bid
Active Comparator Drug,Active Comparator Drug
Nail gutter method plus topical 0.5% timolol bid,topical 0.5% timolol bid alone
Sponsors
Faculty of Medicine Siriraj Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Cancer patients aged more than 18 years who received EGFR inhibitors therapy 2. Patients have more than two paronychia/pyogenic granuloma of finger/nail (CTCAE paronychia grade 2 and 3) that affect their everyday life.
Exclusion criteria
Exclusion criteria: Patients with underlining diseases: asthma,COPD, arrhythmia, Patients who have infected nail that lead to nail extraction. Patients with neutropenia and thrombocytopenia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response 8 weeks after primary intervention Complete response (CR), Partial response (PR), No response score (NR) | — |
Secondary
| Measure | Time frame |
|---|---|
| SPOT score ,VAS,CTCAE paronychia grading within 8 weeks after primary intervention Doctor evaluate response | — |
Countries
Thailand
Contacts
Public ContactLeena Chularojanamontri
Faculty of Medicine, Mahidol University
Outcome results
None listed