Postoperative nausea and vomiting PONV Postoperative nausea and vomiting Lidocaine Xylocaine Mastectomy Breast surgery
Conditions
Interventions
Lidocaine is local anesthetic drug that has shown to improve chronic pain in breast surgery and PONV in various surgery
Dose 1.5 mg/kg iv bolus then 2 mg/kg/hr(0.1mL/kg/hr),0.9% NSS 10 mL IV bolus the
Experimental Drug,Placebo Comparator Drug
Lidocaine group,0.9% NSS
Sponsors
Faculty of medicine, Khon Kaen University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Female 18-65 years old ASA 1-3 Undergoing breast surgery in Srinagarind hospital
Exclusion criteria
Exclusion criteria: History of smoking History of anti-emetic drug in 48 hour Lidocaine allergy Chronic opioid/anti-cholinergic use Cirrhosis or abnormal liver function test Creatinine less than 60 Arrhythmia/AV block/HR less than 50 bpm Myocardial ischemia Contraindication for NSAIDs BMI more than 30
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of PONV 1 hr, 6 hr, 24 hr postoperative Incidence | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of PONV 1 hr, 6 hr, 24 hr postoperative Score in percentage (mild,moderate,severe),Total anti-emetic drug consumption 24 hr Average total dose in mg,Total opioid consumption 24 hr Average total dose in mg | — |
Countries
Thailand
Contacts
Public ContactChudapha Napom
Center for Ethics in Human Research, Khon Kaen University
Outcome results
None listed