Dysphagia Swallowing physiology Esophageal dysphagia Esophageal manometry Esophageal mano-fluoroscopy
Conditions
Interventions
healthy volunteer,healthy volunteer,healthy volunteer
age 20-40 yr,age 41-60 yr,age 61-80 yr
Sponsors
The Royal College of Physicians of Thailand (RCPT)
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age 20-80 years Swallowing disturbance questionnaire (SDQ) score below 0.5 Able to follow commands On a regular diet at home
Exclusion criteria
Exclusion criteria: Unable to communicate and answer the SDQ Uncontrolled medical conditions including unstable vital signs, COPD, or asthma exacerbation The presence of esophageal dysmotility symptoms such as heartburn, chest pain, regurgitation, chronic cough, hoarseness of voice, nausea and vomiting History of disease or disorder that altered esophageal function such as stroke, Parkinsons disease, Alzheimer, motor neuron disease, multiple sclerosis, oropharyngeal anatomical distortion from head and neck cancer, sarcopenia, GERD, and achalasia Chronic disease involving vital organs including heart, brain, kidney, liver, lung, CNT disease, psychiatric problems, severe OSA, poor controlled DM except for HT, DLP BMI less than 18.5 or greater than 25 or weight loss of more than 5 percent over 6 to 12 months History of head and neck surgery, esophageal or gastric surgery Using prokinetics, antispasmodics, muscle relaxants, anti-cholinergic, opioids, nitrate, calcium channel blocker, antidepressant, and beta adrenergic antagonist within 1 week cannot withhold medication during the period of the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Esophageal wall distension at the beginning of study Metric of esophageal manometry | — |
Secondary
| Measure | Time frame |
|---|---|
| Esophageal clearance at the beginning of study FLuoroscopy | — |
Countries
Thailand
Contacts
Public ContactNanicha Siriwong
King Chulalongkorn Memorial Hospital
Outcome results
None listed