Investigation of The Effect of Vitamin D Supplementation on Apical Lesion Healing Rate: Prospective, Randomized Clinical Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20221020006

Enrollment

Registered

2022-10-20

Start date

2021-02-18

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

vitamin D deficiency and apical periodontitis Vitamin D, apical periodontitis, endodontics, fractal

Interventions

Measurement of 25OHD levels will be repeated at 3-month intervals at the beginning of endodontic treatment and after 3, 6, 9 and 12 months. 25OH vitamin D levels will be studied by chemiluminescence

Active Comparator Drug,No Intervention Procedure/Surgery

root canal treatment and vitamin D replacement,root canal treatment

Eligibility

Sex/Gender

Male

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Systemically healthy, 2. 25(OH) vitamin D level between 20-30 ng/ml, 3. Non-smoker 4. Male patients who do not take additional vitamin D supplements externally, 5. Devital, closed apex mandibular molar teeth with a periapical lesion of 5 mm or more involving only one root (referring to the largest diameter of the lesion).

Exclusion criteria

Exclusion criteria: 1. 25(OD) vitamin D value < 20 ng / mL patients, 2.Female patients, 3. Patients with bone metabolism disease and/or patients using drugs (such as steroids, bisphosphonates) that will affect bone metabolism, 4. Patients with a history of radiotherapy, 5. Individuals with diabetes, chronic kidney failure and/or thyroid disease, 6. Patients with sclerosing osteitis, osteosclerosis or any bone pathology (cyst, tumor) in the quadrant of the tooth to be treated, 7. Generalized chronic periodontitis patients 8. Having a periodontal lesion smaller than 5 mm and a periodontal pocket deeper than 3 mm, 9. Developmental anomaly 10. Teeth with a combined lesion involving both roots.

Design outcomes

Primary

Measure	Time frame
vitamin D AFTER BLOOD SAMPLE IS TAKEN kemiluminesans method	—

Secondary

Measure	Time frame
periapical lesion healin after checkup appointments fractal analysis with Image J	—

Countries

Turkey

Contacts

Public ContactEDANUR MARAS

RECEP TAYYIP ERDOGAN UNIVERSITY

dis@erdogan.edu.tr90464220000

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026