18 years and older thai participants who have Fuchs Endothelial corneal Dystrophy with clinical presentation of Photophobia or night blindness with Snellen Best Corrected Visual Acuity lower than 20/40 with modified Krachmer grading of corneal dystrophy not more than gr.IV Fuchs Endothelial Corneal Dystrophy , Fuchs Endothelial Dystrophy , FECD ,FED ,Descemet Stripping Only , DSO
Conditions
Interventions
DSO is performed by remove the small central corneal Descemets membrane only. and post operative use of 0.4% Ripasudil qid wait to see if the surrounding endothelial cells migrate from the periphery t
Experimental Procedure/Surgery
Descemets Stripping Only (DSO)
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.18 years and older thai participants 2.Patient who have Fuchs Endothelial corneal Dystrophy with clinical presentation of 2.1 Photophobia or visual problems in dim light . 2.2 Snellen Best Corrected Visual Acuity lower than 20/40 2.3 Modified Krachmer grading of corneal dystrophy not more than gr.IV with peripheral corneal endothelial cells greater than 1,000 cells/mm2 and corneal thickness 580-640 um
Exclusion criteria
Exclusion criteria: 1.No light perception 2.Have chronic disease that effect on wound healing process , or uncontrolled underlying disease eg. uncontrolled Hypertension and Chronic kidney disease. 3.Immunocopromise patient. 4.Not well co-operative patient or patient who's inconvenient to follow-up 5.Patient who have other eye pathology that effects on vision eg. infectious/autoimmune keratitis or significant cataract 6.History of Rho Kinase Inhibitors drug allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| visual outcome at 12 months after intervention visual acuity, Endothelial cell count, Corneal Thickness | — |
Secondary
| Measure | Time frame |
|---|---|
| complication of DSO surgery 12 months after intervention visual acuity, Endothelial cell count, Corneal Thickness | — |
Countries
Thailand
Contacts
Public ContactVilavun Puangsricharern
Faculty of Medicine, Chulalongkorn University
Outcome results
None listed