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Effectiveness of nifedipine, labetalol, and hydralazine as emergency antihypertension in severe preeclampsia

Effectiveness of nifedipine, labetalol, and hydralazine as emergency antihypertension in severe preeclampsia

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
TCTR
Registry ID
TCTR20221014007
Enrollment
39
Registered
2022-10-14
Start date
2021-06-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe preeclampsia Preeclampsia

Interventions

Nifedipine was administered 3 doses within 60 minutes (i.e., 20 minutes interval). Dose of oral nifedipine was (20 mg). ,Labetalol was administered 3 doses within 60 minutes (i.e., 20 minutes interva
Active Comparator Drug,Active Comparator Drug,Active Comparator Drug
Nifedipine,Labetalol,Hydralazine

Sponsors

Local, in Arifin Achmad Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: All pregnant women with a diagnosis of severe preeclampsia. Gestational age of 28 to 34 weeks. Live fetus. Upper arm circumference 23.5 to 33 cm. Willing to participate in research. Hemoglobin level 10.5 g/dl.

Exclusion criteria

Exclusion criteria: 1. Pregnant women with severe preeclampsia with decreased consciousness. 2. Pregnant women with severe preeclampsia accompanied by complications/complications such as eclampsia, HELLP syndrome, kidney failure, or acute pulmonary oedema. 3. Pregnant women with severe preeclampsia in labor. 4. Pregnant women with severe preeclampsia who received antihypertensive therapy in the last 12 hours. 5. Pregnant women with severe preeclampsia who have a history of allergy to the trial drug. 6. Pregnant women with severe preeclampsia who have a history of asthma and heart disease.

Design outcomes

Primary

MeasureTime frame
Blood pressure 6 hours Direct assessment

Secondary

MeasureTime frame
Subjective side effect 6 hours Interview

Countries

Indonesia

Contacts

Public ContactDonel Suhaimi

Fakultas Kedokteran Universitas Riau

donelmy@yahoo.com0811660685

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026