Healthy condition Purple waxy corn functional beverage anthocyanin dietary fiber
Conditions
Interventions
Subjects received the placebo product which has the same color and smell and looks like grains-based beverages containing functional compounds.,Subjects received grains-based beverages containing func
Placebo,Grains-based beverage containing functional compounds 2 g/day,Grains-based beverage containing functional compounds 4 g/day
Sponsors
National Research Council of Thailand (NRCT)
Eligibility
Sex/Gender
All
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 45-65 years old 2. All volunteers don't have cardiovascular diseases or lung disease 3. All volunteers don't get medicine such as anti-inflammatory agents, beta 2-agonists, or other supplements before the start of the test.
Exclusion criteria
Exclusion criteria: 1. Volunteers who have been diagnosed with one of the following; allergies, liver disease, kidney disease, and head injury 2. Drinking alcohol more than 5 times/day 3. Smoking more than 10 pieces/day 4. Volunteers who have regular exercise more than 3 times/week 5. Volunteers who participate in other projects
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tumor necrosis factor-alpha 2 months ELISA method | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of Inflammatory markers (IL-4, IL-6, IL-10, IL 1 beta, and C-reactive protein) 2 months ELISA method,Evaluation of Immune markers (CD4, CD8, and CD4+/CD8+ T cell ratio) 2 months ELISA method,Evaluation of Oxidative stress markers; MDA, SOD, CAT, GSH-Px, Nrf2, 8-OHDG, and Sirtuin-1 2 months ELISA method,Evaluation of Neurotransmitters; Acetylcholinesterase and Monoamine oxidase activity 2 months laboratory,Evaluation of Metabolic profiles; Insulin, HbA1C, and HOMA-IR 2 months laboratory,Evaluation of Epigenetic markers; HAT, HDAC, and DNMT1 2 months laboratory,Evaluation of Genetic polymorphism; CYP3A4, CYP3A5*3, and Arc 2 months laboratory,Stool examination; PH, Lactic acid-producing bacteria, Lactobacillus spp., Bifidobacterium spp., and Short chain fatty acid 2 months laboratory,Evaluation of Dynamic lung function; FVC, FEV1, and FEV1/FVC 2 months equipment,The changes of Event-Related Potentials (ERPs) and Computerized battery test 2 months equipment,The changes of Electrocardiogram 2 months Electrocardiography,The changes of hematological and clinical chemistry parameters 2 months laboratory | — |
Countries
Thailand
Contacts
Public ContactJintanaporn Wattanathorn
Faculty of Medicine, Khon Kaen University
Outcome results
None listed