Agricultural workers receiving organophosphate and carbamate pesticides Lysiphyllum strychnifolium extract organophosphate and carbamate pesticides agricultural workers
Conditions
Interventions
Yanangdaeng extracted 1000 mg per day - 250 mg x 4 capsules for 14 days
,placebo 4 capsules per day for 14 days
Experimental Drug,Placebo Comparator No treatment
Yanangdaeng,Placebo
Sponsors
Agricultural Research Development Agency (ARDA)
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Agricultural workers receiving organophosphate and carbamate pesticides both male and female between the ages of 20 and 45 years 2. The level of cholinesterase is less than 87.5 units/ml examined using the Reactive paper technique 3. Non-lactating and non-pregnant females 4. Absence of underlying disease or history of significant clinical conditions, particularly liver, kidney, and cardiovascular diseases or any other body system 5. No history of drug allergy and food allergy 6. No current use of medicines, including herbal medicines 7. No history of alcoholism (alcohol abuse) 8. No history of drug abuse or drug addiction 9. Ability to communicate effectively with study personnel
Exclusion criteria
Exclusion criteria: 1. The level of cholinesterase is less than 1 kU/L 2. Clinically significant abnormal findings from physical examination and routine laboratory tests (blood chemistry, hematology, and urinalysis) during screening 3. Participation in other clinical studies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety of Lysiphyllum strychnifolium extract 1 month Sign, symptom, and laboratory results | — |
Secondary
| Measure | Time frame |
|---|---|
| Efficacy of Lysiphyllum strychnifolium extract on reducing blood toxins in agricultural workers 1 month Sign, symptom, and laboratory results | — |
Countries
Thailand
Contacts
Public ContactPiracha Jumpangern
Chulabhorn International College of Medicine, Thammasat University
Outcome results
None listed