Acute kidney injury and urinary [TIMP-2] x [IGFBP7] in patient hospitalized for acute heart failure Acute kidney injury, urinary [TIMP-2] x [IGFBP7], nephrocheck, acute heart failure, acute decompensated heart failure, SGLT2 inhibitor, renal function, biomarker
Conditions
Interventions
SGLT2 inhibitor for add on therapy in acute heart failure patients for 28 days,Standard therapy in diuretic treatment in acute heart failure patients
SGLT2 inhibitor,Standard therapy
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. acute decompensated heart failure 1.1 dyspena at rest or dyspnea on minimal exertion 1.2 signs of pulmonary congestion 1.3 NT- proBNP more than 1600 pg/ml or more than 2000 pg/ml in atrial fibrillation patients 2. No vasodilator intravenous within 6 hours 3. No vasopressor and inotropic drug intravenous within 6 hours
Exclusion criteria
Exclusion criteria: 1. Type 1 diabetes 2. History of diabetic ketosis or ketosis 3. GFR (CKD-EPI) < 30 ml/min/1.73 square meter 4. History of prior SGLT2 inhibitor 5. Systolic blood pressure < 100 mmHg 6. Cardiogenic shock 7. History of percutaneous coronary intervention within 30 days before enrollment or planned for percutaneous coronary intervention 8. Immunosuppressive agent use 9. Acidemia with pH < 7.2 10. Sepsis or septic shock 11. Liver failure 12. Pregnancy or breast feeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AKI 0,1,2,3,7,14,28 days after enrollment Creatinine,Change in [TIMP-2] x [IGFBP7] 0, 7, 28 days after enrollment Nephrocheck | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in GFR 0,1,2,3,7,14,28 days after enrollment CKD-EPI,Length of stay 28 days after enrollment Researcher reports from medical data,Urine output 1, 2, 3 days after enrollment Measurement of urine output per day,Adverse event 28 days after enrollment Patients and researcher report adverse event ,28-day mortality 28 days after enrollment Resercher reports from medical record | — |
Countries
Thailand
Contacts
Public ContactJananya Wattanakul
Bhumibol Adulyadej Hospital
Outcome results
None listed