Prophylactic Ondansetron plus Phenylephrine and Placebo plus Phenylephrine Intravenous Slow Injection on Vasopressor Consumption, Hypotension and Bradycardia after Spinal Anesthesia in Patients Undergoing Cesarean Section: a Randomized, Single-Blind Study

A Comparison of Prophylactic Ondansetron plus Phenylephrine and Placebo plus Phenylephrine Intravenous Slow Injection on Vasopressor Consumption, Hypotension and Bradycardia after Spinal Anesthesia in Patients undergoing Cesarean Section : A Randomized, Single-Blind Study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20221001007

Enrollment

100

Registered

2022-10-01

Start date

2023-01-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy pregnancy prophylactic, ondansetron, phenylephrine, hypotension, cesarean section

Interventions

Ondansetron+Phenylephrine,Placebo+phenylephrine

Experimental Drug,Experimental Drug

OP,PP

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. ASA physical status II or III 2. BMI <=30 kg/m2 3. age more than or equal 18 years old 4. singleton 5. term preganancy (GA more than or equal 37 weeks)

Exclusion criteria

Exclusion criteria: 1. ondansetron injection less than 10 mins before SA 2. cerebrovascular disease 3. complicated pregnancy (eg. placenta previa, abruptio placantae) 4. major fetal anomalies 5. history of monoamine oxidase inhibitor (MAOI) use 6. other drugs administration before baby delivery

Design outcomes

Primary

Measure	Time frame
vasopressor comsumption before baby delivery case record form	—

Secondary

Measure	Time frame
hypotension before baby delivery case record form	—

Countries

Thailand

Contacts

Public ContactRatikorn Anusorntanawat

Chaophrayayommarat hospital

netanesth@hotmail.com0819424915

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026