Postoperative pain in patients undergoing complex spine surgery Pain, Postoperative Laminectomies Naloxone
Conditions
Interventions
NSS 500 ml + naloxone total dose 0.25mcg/kg/hr IV 21mL/hr,NSS 500 ml IV 21mL/hr
Active Comparator Drug,Placebo Comparator No treatment
Naloxone (N),Placebo (C)
Sponsors
Faculty of Medicine, Chiang Mai University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Elective Open complex spine Surgery 2. Age 18-70 3. The American Society of Anesthesiologists (ASA) physical status classification I-III
Exclusion criteria
Exclusion criteria: 1. History of previous spine surgery 2. Hepatic or renal failure 3. Chronic opioid use 4. Allergy or contraindicated to medications used in study protocol - Refuse to participate or withdraw their consent at any stage of the study - Inability to understand the VAS or to operate the PCA device
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Average pain intensity Within 24 hr post operatively Visual Analogue Scale (VAS) | — |
Secondary
| Measure | Time frame |
|---|---|
| Total morphine consumption 6,12,24,48 hours postoperatively mg,Pain intensity 0,6,12,24,48 hours postoperatively Visual Analogue Scale (VAS),Side effect of morphine (Nausea&Vomiting , Pruritus, Respiratory depression) required treatment within 24 hr post operatively Patient report,Time to first rehabilitation The day the patient can sit by themselves Patient report,Length of stay in the hospital The day the patient discharge from the hospital Days,Patient satisfaction before discharge from the hospital Patient Global Impression of Change (PGIC) scale | — |
Countries
Thailand
Contacts
Public ContactIsarapong Pianngarn
Faculty of Medicine, Chiang Mai University
Outcome results
None listed