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Effects of caffeine dose on bowel function recovery following gynecologic cancer surgery: A randomized double-blind controlled trial

Effects of caffeine dose on bowel function recovery following gynecologic cancer surgery: A randomized double-blind controlled trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20221001002
Enrollment
92
Registered
2022-10-01
Start date
2022-01-02
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bowel function recovery following gynecological cancer surgery coffee, ileus, gynecological cancer

Interventions

Drinking three cups of coffee with 100 mg caffeine in hot water 100 mL in one day, beginning on the morning after surgery at 7.00, 12.00, 17.00 within 30 minutes under the supervision (a nurse or a do
Active Comparator Other,Active Comparator Other
100 mg caffeine,50 mg caffeine

Sponsors

None listed

Eligibility

Sex/Gender
Female
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients age between 18 to 75 years old who diagnosed with cervical cancer, endometrial cancer, ovarian cancer and other cancer and scheduled for surgery.

Exclusion criteria

Exclusion criteria: 1.Patients with a history of allergy to coffee or caffeine. 2.Patient with liver disease, acute or chronic kidney disease, cardiac arrhythmia, function thyroid disease and inflammatory bowel disease. 4.Patient with history of chronic diarrhea or chronic constipation (defined as two or fewer bowel movements per week) 3.Patient with a history of prior abdominal bowel re-anastomosis surgery. 5.Patient who need for intensive care or endotracheal tube for more than 24 h postoperatively. 6.Patient who need for nasogastric tube drainage beyond the first postoperative morning. 7. Patients who suffered from intestinal injuries and received intestinal repaired during surgery.

Design outcomes

Primary

MeasureTime frame
the time to first flatus after drink coffee based on the patient own statements

Secondary

MeasureTime frame
time to first defecation after drink coffee base on patient own statements,time to normal bowel sound after surgery audible bowel sound three time a day after surgery by investigators,time to tolerate solid diet observe by investigators patient tolerate to intake solid food without nausea or vomiting within 4 hours after meal,length of hospital stay the period until admit to discharge the period until admit to discharge

Countries

Thailand

Contacts

Public ContactYaowapa Jirawongprapa

UdonThani Hospital

alowana_pf@hotmail.com6642245555

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026