Cirrhosis patients with prolong clotting time Plasma transfusion Cirrhosis Restrictive Bleeding
Conditions
Interventions
No plasma transfusion in cirrhosis patients with prolonged clotting time who undergo an invasive procedure.,2 units of plasma will be transfused in cirrhosis patients with prolonged clotting time who
Experimental No treatment,No Intervention Procedure/Surgery
Restrictive FFP transfusion,Conventional FFP transfusion
Sponsors
Chulalongkorn University
The Royal College Physicians of Thailand
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Cirrhosis patients diagnosed by clinical signs and/or liver function tests and/or imaging and/or liver biopsy, 2. Baseline international normalized ratio (INR) 1.5 to 2.5, 3. Have a history of esophageal varice, 4. Undergoing a prophylaxis esophageal band ligation.
Exclusion criteria
Exclusion criteria: 1. Hereditary or acquired coagulopathy other than liver diseases, 2. Evidence of hemodynamic instability, 3. History of active infection within 2 weeks, 4. Renal insufficiency (Creatinine 2.0 mg/dL or over), 5. Taking antiplatelet and/or anticoagulant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bleeding complication rate At 2 weeks after end of the intervention Major bleeding according to ISTH definition | — |
Secondary
| Measure | Time frame |
|---|---|
| Transfusion rate 24 hours after initiate the intervention The plasma transfusion event. Yes or No.,Transfusion-related adverse events Within 24 hr after end of the intervention National Healthcare Safety Network (NHSN) Hemovigilance Module,Mortality rates Within 3 months after end of the intervention Number of Mortality in each arm | — |
Countries
Thailand
Contacts
Public ContactNuanrat Cheerasiri
Department of Medicine, Faculty of Medicine, Chulalongkorn University, and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand
Outcome results
None listed