Safety and Effects of Lactobacillus paracasei TISTR 2593 Supplementation on Improving Cholesterol Metabolism and Atherosclerosis-related parameters in Subjects with Hypercholesterolemia

Safety-Consumption and Cholesterol-Lowering Effects of Lactobacillus paracasei TISTR 2593 by the Alternating Cholesterol Metabolism and Parameters Associated with Atherosclerosis in Hypercholesterolemic Subjects

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20220917002

Enrollment

Registered

2022-09-17

Start date

2021-11-05

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild and Moderate Hypercholesterolemia Lactobacillus paracasei

Interventions

L. paracasei TISTR 2593 maltodextrin capsule which received form Expert Center of Innovative Health Food, Thailand Institute of Scientific and Technological Research, Thailand at a daily dose 1.05 g

Experimental Dietary Supplement,Placebo Comparator Dietary Supplement

Probiotic Lactobacillus paracasei TISTR 2593 capsule,Placebo

Eligibility

Sex/Gender

All

Age

30 Years to 65 Years

Inclusion criteria

Inclusion criteria: Subjects were eligible for the study both male and female (non-pregnant), aged 30 to 65 years, mild and modulate hypercholesterolemia, BMI between 19 and 30 kg/m2, no a vegan and vegetarian and no cholesterol and triglycerides lowering drug.

Exclusion criteria

Exclusion criteria: In the case of a previous cardiovascular event within the last 6 months, the presence of secondary dyslipaemias.

Design outcomes

Primary

Measure	Time frame
Blood lipid profiles (TG, TC, LDL-C, HDL-C) 0, 45, 90 days Enzymatic colorimetric method,Safety parameter (serum biochemistry, blood electrolytes and complete blood count) 0, 45, 90 days Test by Laboratory Unit of Chiang Mai Medical Lab, Chiang Mai	—

Secondary

Measure	Time frame
Oxidative stress status (MDA and GSH) 0, 45, 90 days Enzymatic colorimetric method,Inflammation biomarkers (IL-10, IL-6 and TNF-alpha ) 0, 45, 90 days Enzyme linked immunosorbent assay kit ,Total bile acid (TBA) 0, 45, 90 days Enzyme linked immunosorbent assay kit,Adiponectin 0, 45, 90 days Enzyme linked immunosorbent assay kit,Apolipoprotein E 0, 45, 90 days Enzyme linked immunosorbent assay kit,MCP-1 0, 45, 90 days Enzyme linked immunosorbent assay kit	—

Measure

Time frame

Oxidative stress status (MDA and GSH) 0, 45, 90 days Enzymatic colorimetric method,Inflammation biomarkers (IL-10, IL-6 and TNF-alpha ) 0, 45, 90 days Enzyme linked immunosorbent assay kit ,Total bile acid (TBA) 0, 45, 90 days Enzyme linked immunosorbent assay kit,Adiponectin 0, 45, 90 days Enzyme linked immunosorbent assay kit,Apolipoprotein E 0, 45, 90 days Enzyme linked immunosorbent assay kit,MCP-1 0, 45, 90 days Enzyme linked immunosorbent assay kit

—

Countries

Thailand

Contacts

Public ContactPennapa Chonpathompikunlert

Thailand Institute of Scientific and Technological Research (TISTR)

jurairat.kh@cmu.ac.th0846861986

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026