hemifacial spasm hemifacial spasm botulinum toxin
Conditions
Interventions
Botulinum toxin administration for periocular muscle
Normal saline administration for peri-oral muscle ,Botulinum toxin administration for periocular muscle and peri-oral muscle
Experimental Drug,Active Comparator Drug
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University.
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.No BoNT-A injections had been given to the face during the preceding 4 months (the BoNT-A washout period).5,15,16 2.There were no other augmentation treatments for HFS, such as oral medications (benzodiazepines, gabapentin, or baclofen). 3.The patients were between 18 and 85 years of age (to ensure cognitive ability for subjective assessments).
Exclusion criteria
Exclusion criteria: 1.Patients unresponsive to BoNT-A (suspected BoNT-A immunogenic cases) 2.Pregnant or lactating women 3.Individuals with a history of serious side effects or known allergies to BoNT-A 4.Patients with muscle weakness disorders, such as myasthenia gravis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| control clinical of hemifacial spasm at 1 month Self reported of disease severity by visual analogue scale (VAS) | — |
Secondary
| Measure | Time frame |
|---|---|
| quality of life Preinjection & at 1 month HFS-30 Thai version,severity grading of HFS preinjection & 1 month Samsung medical center grading system (SMC grade),severity grading of HFS preinjection & 1 month The Hemifacial Spasm Grading Scale | — |
Countries
Thailand
Contacts
Public ContactAkarawit Eiamsamarng
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed