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Low dose Cyproterone acetate as an effective androgen lowering agent: a randomized controlled trial

Low dose Cyproterone acetate as an effective androgen lowering agent: a randomized controlled trial

Status
Unknown
Phases
Unknown
Study type
Observational
Source
TCTR
Registry ID
TCTR20220916001
Enrollment
84
Registered
2022-09-16
Start date
2022-12-15
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Transgender Transwomen Transwomen Transgender low dose cyproterone acetate CPA Gender affirming hormone therapy GAHT

Interventions

42 trans women in this group will receive estrogen 2 mg and CPA 12.5 mg for 3 months ,42 trans women in this group will receive estrogen 2 mg and CPA 25 mg for 3 months
Treatment,Treatment
low dose group ,standard dose group

Sponsors

Faculty of Medicine, Chiang Mai university
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1.Age between 18 to 40 yr 2. never receive any gender affirming hormone therapy before or stop using the hormonal treatment at least 3 months 3. no contraindication for GAHT 4. willing to participate this study 5. can read Thai

Exclusion criteria

Exclusion criteria: 1. underwent gender affirming surgery 2. low baseline testosterone (<250 ng/dL) 3. History of venous thromboembolism 4. Psychological problems 5. Thai Language barrier 6. Hyperkalemia 7. contraindication for GAHR; such as active kidney disease, cancer

Design outcomes

Primary

MeasureTime frame
Estrogen level at 0, 3 months after intervention pg/ml ,testosterone level 0,3 months after intervention ng/mL

Secondary

MeasureTime frame
body change at 3 months after intervention physical examination ,quality of life at 3 months after intervention Patient reported outcome using a questionnaire interview

Countries

Thailand

Contacts

Public ContactRasrawee Chantrasiri

Faculty of Medicine, Chiang Mai University

rcbeautie@gmail.com0873039943

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026