Moderate to severe carpal tunnel syndrome patients requiring carpal tunnel release surgery carpal tunnel syndrome severe carpal tunnel syndrome carpal tunnel release platelet-rich plasma PRP
Conditions
Interventions
All patients will receive standard mini-open CTR, Venipuncture for 18ml of whole blood from the unaffected arm, 2ml of blood will be sent for CBC for the PRP group, 16ml of blood will be used to prepa
Experimental Drug,No Intervention No treatment
Platelet rich plasma (PRP),Standard carpal tunnel release
Sponsors
Faculty of medicine, Siriraj hospital, Mahidol university
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age more than 18 years old 2. Diagnosed with carpal tunnel syndrome using criteria of 2/2 1. Pain or numbness at thumb index middle and radial half of ring finger 2. a positive physical examination of Tinel's sign or Phalen test, or Durkan test 3. Electrodiagnostic confirmed with moderate to severe carpal tunnel syndrome according to American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM) guideline 4. Persist symptoms at least 3 months after conservative treatment and requiring carpal tunnel release surgery
Exclusion criteria
Exclusion criteria: 1. Previous PRP or steroid injection in 6 months 2. History of Inflammatory joint disease e.g. RA, SLE, gouty arthritis 3. History of Peripheral neuropathy, Cervical spondylosis radiculopathy 4. Previous fracture/injury or surgery on the affected hand 5. Cognitive impairment 6. History of Thrombocytopenia or Thrombocytosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Thai version BCTQ 3 month Thai version boston carpal tunnel questionaire (BCTQ) | — |
Secondary
| Measure | Time frame |
|---|---|
| Thai version BCTQ 2 weeks, 6 weeks, 6months BCTQ Thai version boston carpal tunnel questionaire (BCTQ),Patient satisfaction 2 weeks, 6 weeks, 3 months, 6months 5-point Likert scale,Pinch strength 2 weeks, 6 weeks, 3 months, 6months Pinch strength (kg),Hand grip strength 2 weeks, 6 weeks, 3 months, 6months Hand grip strength (kg) ,Number of Acetaminophen use 2 weeks total mg of acetaminophen used during 2 weeks post-operatively,Pain score 2 weeks, 6 weeks, 3 months, 6months Numerical Rating Scale (NRS) pain 0-10 point,Post-operative numbness 2 weeks, 6 weeks, 3 months, 6months Complete resolution, Incomplete resolution, No improvement (compare with preoperative)),Neuropathic pain 2 weeks, 6 weeks, 3 months, 6months Thai Language of the Neuropathic Pain Diagnostic Questionnaire (DN4),Pressure sensation 2 weeks, 6 weeks, 3 months, 6months Semmes-Weinstein monofilament test (SWMF),Electrodiagnostic study parameter 3 months Sensory latency (msec), Sensory conduction (m/s) , SNAP amplitude (microV), Distal motor latency (msec) Motor conduction (m/s) Distal CMAP amplitude (mV),Postoperative complication 2 weeks, 6 weeks, 3 months, 6months surgical site infection, wound dehiscence, pillar pain, reoperation rate | — |
Countries
Thailand
Contacts
Public Contactkorawish mekariya
Faculty of Medicine, Siriraj Hospital, Mahidol University
Outcome results
None listed