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Optimal propofol concentration at effect site for esophagogastroduodenoscopy under total intravenous anesthesia with target controlled infusion

Optimal propofol concentration at effect site for esophagogastroduodenoscopy under total intravenous anesthesia with target controlled infusion

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20220829004
Enrollment
40
Registered
2022-08-29
Start date
2017-01-10
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sedation in esophagogastroduodenoscopy EGD Sedation TCI

Interventions

Effect-site concentration (Cet) in the first patient would be 2 or 3 ug/mL depending on age. Observe somatic response and gag reflex during scope insertion. record target effect-site concentration wit
Experimental Procedure/Surgery
Moderate to deep sedation with propofol using TCI in EGD procedure

Sponsors

Khon Kaen University, Thailand
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients aged at least 18 years with ASA physical statuses of 1-3 who were scheduled for an elective EGD under TIVA at Srinagarind Hospital.

Exclusion criteria

Exclusion criteria: Patients who had a body mass index greater than 30 Kg/m2; were hypersensitive to propofol, eggs, or soybeans; or had a history of coronary vascular, respiratory, or cerebrovascular disease

Design outcomes

Primary

MeasureTime frame
Optimum Cet of propofol durung EGD probe insertion response during an EGD probe insertion

Secondary

MeasureTime frame
Complication during EGD probe insertion Bradycardia less than 60 BPM, Desaturation less than 95%

Countries

Thailand

Contacts

Public Contactnonthida rojanapithayakorn

Faculty of Medicine, Mahidol University

nonthida.roj@mahidol.ac.th024197990

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026