Effect of Curcuminoid Pastille on the Management of Dry Mouth in Elderly Patients

Effect of Curcuminoid Pastille on the Management of Dry Mouth in Elderly Patients with Hypertension and Diabetes Mellitus

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20220817003

Enrollment

Registered

2022-08-17

Start date

2021-09-06

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elderly patients with hypertension and diabetes mellitus who have dry mouth. Dry mouth, Xerostomia, Elder, Curcuminoid pastille, Oral mucositis, Saliva

Interventions

Baseline or no intervention,Recommendations according to the Ministry of Public Health standards. Basic advice includes water sipping and avoiding sun exposure.,Pastille base without the active ingred

No Intervention No treatment,No Intervention Behavioral,Placebo Comparator Drug,Experimental Drug

Baseline,Standard recommendation,Placebo pastille,Curcuminoid pastille.

Eligibility

Sex/Gender

All

Age

60 Years to 75 Years

Inclusion criteria

Inclusion criteria: Elderly aged 60-75 who received services at the diabetes blood pressure clinic for at least 1 year, having mild to moderate dry mouth assessed by the Shortening Xerostomia Inventory with a score of greater than or equal to 7, and consent to participate in the study.

Exclusion criteria

Exclusion criteria: Patients whose salivary gland has been destroyed, and cannot produce saliva; allergic to curcumin; have cholangitis Clogged bile duct; have a mental disorder; do not have dry mouth assessed by the Shortening Xerostomia Inventory with a score of less than 7.

Design outcomes

Primary

Measure	Time frame
subjective dry mouth Baseline, 2 weeks after basic recommendations on water sipping, 2 weeks after using placebo or curcuminoid pastille. Shortening Xerostomia Inventory and Visual Analog Scale (VAS),objective dry mouth Baseline, 2 weeks after basic recommendations on water sipping, 2 weeks after using placebo or curcuminoid pastille. Clinical Oral Dryness Scale,salivary flowrate Baseline, 2 weeks after basic recommendations on water sipping, 2 weeks after using placebo or curcuminoid pastille. stimulated salivary flowrate,oral mucositis Baseline, 2 weeks after basic recommendations on water sipping, 2 weeks after using placebo or curcuminoid pastille. Oral Mucositis Scale, WHO	—

Measure

Time frame

subjective dry mouth Baseline, 2 weeks after basic recommendations on water sipping, 2 weeks after using placebo or curcuminoid pastille. Shortening Xerostomia Inventory and Visual Analog Scale (VAS),objective dry mouth Baseline, 2 weeks after basic recommendations on water sipping, 2 weeks after using placebo or curcuminoid pastille. Clinical Oral Dryness Scale,salivary flowrate Baseline, 2 weeks after basic recommendations on water sipping, 2 weeks after using placebo or curcuminoid pastille. stimulated salivary flowrate,oral mucositis Baseline, 2 weeks after basic recommendations on water sipping, 2 weeks after using placebo or curcuminoid pastille. Oral Mucositis Scale, WHO

—

Secondary

Measure	Time frame
salivary pH Baseline, 2 weeks after basic recommendations on water sipping, 2 weeks after using placebo or curcuminoid pastille. salivary pH using pH strip,Salivary buffer Baseline, 2 weeks after basic recommendations on water sipping, 2 weeks after using placebo or curcuminoid pastille. using GC Saliva Check-Buffer kits (GC Asia, Singapore) ,Patient satisfaction after using placebo and curcuminoid pastille. Questionnaire	—

Measure

Time frame

salivary pH Baseline, 2 weeks after basic recommendations on water sipping, 2 weeks after using placebo or curcuminoid pastille. salivary pH using pH strip,Salivary buffer Baseline, 2 weeks after basic recommendations on water sipping, 2 weeks after using placebo or curcuminoid pastille. using GC Saliva Check-Buffer kits (GC Asia, Singapore) ,Patient satisfaction after using placebo and curcuminoid pastille. Questionnaire

—

Countries

Thailand

Contacts

Public ContactAngkana Thearmontree

Prince of Songkla University

angkana.t@psu.ac.th074287650

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026