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Effect of early postextubation high flow nasal cannula vs conventional low flow oxygen therapy on reintubation in postoperative patients from prolonged general anesthesia at surgical ICU: A Randomized Clinical Trial

Effect of early postextubation high flow nasal cannula vs conventional low flow oxygen therapy on reintubation in postoperative patients from prolonged general anesthesia at surgical ICU: A Randomized Clinical Trial

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
TCTR
Registry ID
TCTR20220805002
Enrollment
260
Registered
2022-08-05
Start date
2022-06-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative patients from prolonged general anesthesia at surgical ICU High flow nasal cannula Reintubation Postoperative patients Prolonged general anesthesia Intensive care unit

Interventions

High flow nasal cannula flow 40 to 60 LPM with FiO2 from 0.3 to 0.4,Oxygen cannula flow 3 to 5 LPM
Active Comparator Device,No Intervention Device
High flow nasal cannula,Low flow oxygen cannula

Sponsors

Siriraj hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 110 Years

Inclusion criteria

Inclusion criteria: All adult patients scheduled for non cardiothoracic surgery All adult patients scheduled for non neurosurgery An anticipated general anesthesia duration of 4 h or more A moderate to high risk of postoperative pulmonary complications ASA classification at least 2 Postoperative observation at surgical ICU

Exclusion criteria

Exclusion criteria: Body mass index greater than 35 Life threatening condition requiring emergency surgery Obstructive sleep apnea syndrome Pregnancy Tracheostomy patients Contraindicated in using HFNC after extubation

Design outcomes

Primary

MeasureTime frame
Reintubation 72 hours Rate—

Secondary

MeasureTime frame
postoperative pulmonary complications 7 days grade,ICU length of stay 30 days Days,Hospital length of stay 90 days Days,Mortality 90 days Rate—

Countries

Thailand

Contacts

Public ContactSirichai Phetuthairung

Siriraj hospital

sirichai.anesthtu@gmail.com0846443363

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026