recurrent aphthous ulcers cannabidiol CBD cannabis recurrent aphthous ulcer RAU recurrent aphthous stomatitis RAS
Conditions
Interventions
0.1% CBD was applied with a calibrated spoon to the ulcers 3 times/day after meals for 7 days. ,0.1% Triamcinolone acetonide (TA) was applied with a calibrated spoon to the ulcers 3 times/day after m
0.1% CBD,0.1% Triamcinolone acetonide (TA),Placebo (pure oral paste)
Sponsors
Thailand Science Research and Innovation Fund Chulalongkorn University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Willing to participate and provide informed consent, 2. Had a history of RAU (at least 2 times/year) on nonkeratinized oral mucosa, 3. Presenting with 1-3 aphthous ulcers (of less than or equal to 48 hours duration) that were 2-10 mm in diameter and easily accessible for evaluation
Exclusion criteria
Exclusion criteria: 1. History of allergies to CBD, 2. Pregnancy/lactation, 3. Concurrent oral bacterial/fungal/viral infections, 4. Ulcers as a manifestation of a systemic disease such as Crohn's disease, Behcet's syndrome, or anemia, 5. Ulcers from trauma, 6. Diabetes mellitus patients, 7. Treatment with systemic steroids, oral retinoids, or other immunomodulatory agents within 1 week, 8. Treatment with nonsteroidal anti-inflammatory drugs, acetaminophen, or oral topical medications within 48 hours or during project participation, 9. History of dental surgery within 2 weeks of entering the study, 10. Orthodontic braces or retainers that might come in contact with the ulcer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pseudomembranous ulcer size Day 0, 2, 5, and 7 Adjusted percentage area | — |
Secondary
| Measure | Time frame |
|---|---|
| Erythematous border size Day 0, 2, 5, and 7 Adjusted percentage area,Pain ratings 7 days Adjusted percentage Visual Analog Scale (VAS),Subject satisfaction The last visit Satisfaction score,Quality of life The first and last visit OHIP-14 score | — |
Countries
Thailand
Contacts
Public ContactChalapinyo Umpreecha
Faculty of Dentistry, Chulalongkorn University
Outcome results
None listed