Changes in plasma metabolomes & effects of ONS in thalassemia with malnutrition

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20220802003

Enrollment

100

Registered

2022-08-02

Start date

2021-02-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metabolomic in thalassemia with manutrition NT-2013, metabolomic, thalassemia, malnutrition

Interventions

Thalassemia with malnutrition by nutrition assessment (NT-2013) will be receive high-calories diets and/or protein supplementation by a nutritionist that calculated by total daily energy expenditure (

Experimental Dietary Supplement,Placebo Comparator Other

Oral nutritional supplement (ONS),Only nutritional advice

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Thalassemia patient diagnosed by HPLC method 2. Accept to enrollment and give an inform consent

Exclusion criteria

Exclusion criteria: 1. Inherited metabolic disorders 2. Liver disease 3. Renal parenchymal disease (eGFR < 60) 4. Other hemolytic anemia 5. Multiple myeloma 6. Malignancy 7. Active infection 8. Chronic alcohol drinking

Design outcomes

Primary

Measure	Time frame
Prevalence of malnutrition 0 weeks Nutrition assessment 2013	—

Secondary

Measure	Time frame
Changes of anthropometry 12 weeks Anthropometric measurement,Changes of Plasma metabolomic 12 weeks LC coupled with quadrupole time-of-flight MS (LC/Q-TOFMS) ,Changes of NT-2013 12 weeks NT-2013,Changes of TMAO 12 weeks Plasma	—

Countries

Thailand

Contacts

Public ContactRattana Weerasathain

Faculty of Medicine, Chiang Mai University

rattana.weerasathain@gmail.com0852163259

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

Changes in plasma metabolomes &amp; effects of ONS in thalassemia with malnutrition