A randomized crossover study comparing high-velocity nasal insufflation with automate oxygen controller versus conventional high-velocity nasal insufflation after endotracheal extubation

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20220801007

Enrollment

Registered

2022-08-01

Start date

2022-09-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mechanically ventilated patients who are ready to wean High-flow Mechanically ventilated patient Oxygen therapy Weaning

Interventions

high-velocity nasal insufflation with automate oxygen controller: temperature 37 degree celcius, flow rate 50 L/min and automate oxygen controller with target SpO2 equal to 94% (range between 92-98%)

Experimental Device,Active Comparator Device

high-velocity nasal insufflation with automate oxygen controller,conventional high-velocity nasal insufflation

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Age >/= 18 years 2. Ready to extubate 3. Agree to participate

Exclusion criteria

Exclusion criteria: 1. Uncooperative 2. Hemodynamic instability 3. Tracheostomy status 4. Pregnant woman

Design outcomes

Primary

Measure	Time frame
Time to target SpO2 60 min oxygen saturation	—

Secondary

Measure	Time frame
Minimum and maximum FiO2 60 min FiO2,ROX index 60 min ROX index,Heart rate 60 min heart rate,Transcutaneous CO2 60 min Transcutaneous CO2,respiratory rate 60 min respiratory rate,mean arterial pressure 60 min mean arterial pressure	—

Countries

Thailand

Contacts

Public ContactNuttapol Rittayamai

Faculty of Medicine Siriraj Hospital, Mahidol University

nuttapol.rit@mahidol.ac.th024197757

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026