Clinical symptoms of the patient with thyroid eye disease and selenium level selenium, thyroid eye disease
Conditions
Interventions
50 healthy participants for assessment of mean selenium level,25 participants receive Selenium 200 mcg. tablets 1 tab per oral once a day dose for 180 days,25 participants receive Placebo tablets 1 ta
No Intervention No treatment,Experimental Dietary Supplement,Placebo Comparator Dietary Supplement
Selenium level,Selenium supplement,Placebo
Sponsors
Office of Research and Development
Eligibility
Sex/Gender
All
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patient aged 20 years or more who was diagnosed with thyroid disease and received the treatment no longer than 3 months 1.1 Thyroid diseases includes hyperthyroidism, hypothyroidism and autoimmune thyroid or 1.2 Patients who diagnosed with thyroid disease and have euthyroid status 2. Healthy participants aged 20 years or more 2.1 No history of thyroid disease 2.2 No status of malnutrition
Exclusion criteria
Exclusion criteria: 1. Patients who received thyroid surgery 2. Patients who received radiotherapy 3. Patients who have lived in Thailand less than a year 4. Patients who have serious illness (e.g. cancer, acute infection) 5. Patient who have severe thyroid eye disease and the treatment by steroid, radiotherapy, or orbital surgery are needed or planned 6. Patient who have selenium level more than 400 micrograms/liter 7. Patient with chronic kidney disease 8. Pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical symptoms and signs of the eyes at 0, 3, 6 and 12 months clinical activity score,subjective quality of life at 0, 3, 6 and 12 months Graves' orbitopathy quality of life,selenium level at 0, 3, 6 and 12 months micrograms per liter | — |
Secondary
| Measure | Time frame |
|---|---|
| Thyroid-Stimulating Hormone at 0, 3, 6 and 12 months milliunits per liter,Triiodothyronine free at 0, 3, 6 and 12 months pg/ml,Free thyroxine at 0, 3, 6 and 12 months pg/ml,Anti-thyroglobulin antibodies at 0, 3, 6 and 12 months IU/ml,Anti-thyroidperoxidase at 0, 3, 6 and 12 months IU/ml,Selenium-rich food consumption score at day 0 points | — |
Countries
Thailand
Contacts
Public ContactPhanuwat Sinthupaeng
Phramongkutklao Hospital
Outcome results
None listed