Contralateral Transcutaneous electrical nerve stimulation (TENS) for phantom limb pain, A prospective randomized controlled trial (CTEP trial)

Status

Unknown

Phases

Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20220722001

Enrollment

120

Registered

2022-07-22

Start date

2021-01-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic phantom limb pain patients Contralateral Transcutaneous electrical nerve stimulation (TENS) phantom limb pain randomized controlled trial

Interventions

Participants assigned to the TENS condition will be administered TENS on the contralateral limb (TENS setting: pulse width 80 ms, frequency 100 Hz, and intensity depends on the patient response but th

Experimental Device,Placebo Comparator Device

TENS ,Placebo

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age more than 18 years. 2. Able to use the 0-10 Numerical Rating Scale (NRS) to rate pain intensity. 3. Patient has phantom limb pain with an average intensity in the past week greater than equal 3 on a 0-10 NRS. 4. Duration of phantom limb pain more than 3 months

Exclusion criteria

Exclusion criteria: 1. Patients cannot understand or express themselves in Thai. 2. Serious psychiatric problem (such as schizophrenia or suicidal ideation with intent) that would interfere with study participation. 3. Contraindicated to receive TENS treatment (e.g., patient with a pace maker, patient spinal cord stimulation or LVAD). 4. Unable to apply TENS at the contralateral limb. 5. Other primary pain conditions or secondary pain associated with other diagnoses such as cancer or severe RLP (i.e., RLP with a greater average severity than PLP). However, although individuals with RLP that is greater in severity than PLP will be excluded from participating in the primary trial, these individuals may be enrolled in the study as RLP participants to pilot the effects of contralateral limb TENS in these individuals.

Design outcomes

Primary

Measure	Time frame
Pain intensity at 14 days of home use of the TENS machine Numeric rating scale	—

Secondary

Measure	Time frame
Pain interference at 14 days of home use of the TENS machine PROMIS-29 Thai,Pain interference at 14 days of home use of the TENS machine Neuropathic Pain Symptom Inventory (NPSI Thai),Quality of life at 14 days of home use of the TENS machine Euroqol 5D5L- Thai	—

Countries

Thailand

Contacts

Public ContactNanticha Kessava

Faculty of Medicine Siriraj Hospital, Mahidol University

nanticha.kes@gmail.com0944142645

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026