Diabetes mellitus type 2 who was treated with Metformin or used to be treated with metformin Metformin intolerance, gastrointestinal intolerance, serotonin transporter gene, SERT
Conditions
Interventions
1. patients who was treated with any dosage of metformin then stopped using the medication due to gastrointestinal symptoms within 6 months after the starting date
,1. patients who was treated with
Treatment,Treatment
Sponsors
Department of medicine, Chulalongkorn University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. patient with diabetes mellitus type 2 2. treated or used to be treated with Metformin (immediate release) 3. Thai patients, aged > 18 years old
Exclusion criteria
Exclusion criteria: 1. patients who withdraw metformin due to other reasons which was not gastrointestinal side effect 2. patients with irritable bowel syndrome 3. patients with inflammatory bowel disease 4. patients with cirrhosis child B or C 5. patients with advanced stage of cancer 6. patient with AIDS 7. pregnant patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serotonin transporter gene genotype At the beginning of study blood for Genetic analysis by Sanger sequencing technique | — |
Secondary
| Measure | Time frame |
|---|---|
| baseline characteristics At the beginning of study data from medical record and interview : age, sex, BMI, comorbidity, medication history, detail of metformin used, lab investigation Ex. FBS, HbA1C, lipid profile, Creatinine | — |
Countries
Thailand
Contacts
Public ContactSutharin Suteetorn
King Chulalongkorn Memorial Hospital
Outcome results
None listed