Comparison the efficacy of single buccal infiltration of 4% articaine with 1:100,000 epinephrine and 2% mepivacaine with 1:100,000 epinephrine during maxillary premolar teeth extraction

Efficacy of single buccal infiltration of 4% articaine with 1:100,000 epinephrine and 2% mepivacaine with 1:100,000 epinephrine during maxillary premolar teeth extraction: a Double-blined randomized controlled trial

Status

Unknown

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20220715003

Enrollment

Registered

2022-07-15

Start date

2022-06-15

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The pain during injecting local anesthesia by palatal infiltration Local Anesthesia , Infiltration Anesthesia

Interventions

The buccal infiltration of Scandonest 2% special (Mepivacaine hydrochloride 2% with epinephrine 1:100,000%) is injected at the lowest point of vestibule of extracting teeth for 1 ml using a 27 gauge n

Experimental Drug,Experimental Drug

Scandonest 2% special (Mepivacaine hydrochloride 2% with epinephrine 1:100,000%),Septanest SP (4% Articaine hydrochloride with epinephrine 1/100,000)

Eligibility

Sex/Gender

All

Age

10 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Participants who have been diagnosed with premolar teeth extraction in the upper jaw on both sides 2. No gender and age limit 3. Be in good health or AHA Classifications I and II 4. Not during the first or third trimester of pregnancy or breast-feeding. 5. Able to receive treatment and follow up at specified intervals

Exclusion criteria

Exclusion criteria: 1. Participants who have any hypersensitivity to amide local anesthetics or components of anesthetics. 2. the premolar teeth have pathological signs and pain or there are periapical lesions. 3. Participants have any soft tissue infection. 4. Participants who received NSAIDs and acetaminophen 24 hours before the study.

Design outcomes

Primary

Measure	Time frame
Onset of local anesthesia after injected local anesthesia Gingival pricking test	—

Secondary

Measure	Time frame
Duration of local anesthesia after local anesthesia was active Patient reported outcome using a interview,Pain during extraction after the procedure a visual analogue scale measuring 100 mm with 0 depicting no pain and 100 depicting severe pain,Complication of extraction within 1 day , 3 day and 7 day after the procedure Patient reported outcome using a interview	—

Countries

Thailand

Contacts

Public ContactKathawut Tachasuttirut

Faculty of Dentistry , Chiangmai university

kathawut.t@cmu.ac.th0845919568

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026