patients with oral lichen planus Oral Lichen Planus, Clobetasol Propionate, Fluocinolone Acetonide, Topical steroid, TNF alpha
Conditions
Interventions
clobetasol propionate 0.05 % gel
sig. apply to lesions tid pc&
hs,fluocinolone acitonide 0.1% in orabase
sig. apply to lesions tid pc&
Experimental Drug,No Intervention Drug
clobetasol propionate,fluocinolone acitonide
Sponsors
Faculty of Dentistry Chiang Mai university ,Chiang Mai, Thailand
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients have been clinically and histologically confirmed as ulcerative and atrophic OLP without evidence of dysplastic changes 2.Patients do not have a history of taking drugs that are reported to cause lichenoid drug reactions and the OLP lesion is not adjacent to dental restoration 3.Patients have neither other oral mucosal lesions nor a history of lichenoid-related systemic conditions
Exclusion criteria
Exclusion criteria: 1.Patients who have received systemic or topical steroid treatment for oral lesions in the past 3 months 2.Pregnant or breast-feeding 3.Smoking or alcohol consumption
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| salivary levels of TNF alpha before treatment, 2 weeks after treatment, 4 weeks after treatment Biochemical analysis | — |
Secondary
| Measure | Time frame |
|---|---|
| symptoms before treatment, 2 weeks after treatment, 4 weeks after treatment visual analog scale,Clinical response before treatment, 2 weeks after treatment, 4 weeks after treatment clinical score | — |
Countries
Thailand
Contacts
Public ContactJITJIROJ ITTICHAICHAROEN
Chiang Mai University
Outcome results
None listed