Pain control effectiveness of curcumin compare with ibuprofen after lower third molar removal surgery and A double blind randomized clinical trial

Status

Unknown

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20220705002

Enrollment

Registered

2022-07-05

Start date

2022-04-24

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who have indication surgical removal of lower third molar Impacted tooth (moderate point of pell and gregory classification) Curcumin, Ibuprofen, Analgesic, impacted tooth, Post operative pain

Interventions

- Step of intervention conclude Prepare medicine, Testing protocol to the surgeon, Recruit people, Surgical of Lower third molar impacted tooth, post-operation instruction (People must note pain score

t know Patient take Curcumin or ibuprofen),- Step of intervention conclude Prepare medicine, Testing protocol to the surgeon, Recruit people, Surgical of Lower third molar impacted tooth, post-operati

Experimental Drug,Experimental Drug

Standard group,Experimental group

Eligibility

Sex/Gender

All

Age

18 Years to 29 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged between 18 to 29 years 2. Weight 40-90 kgs 3. Clear indication for removal of lower third molars 3. Health patients with no uncontrolled systemic disease that is unsuitable to lower the third molar impacted 4. The moderate difficulty of lower third molar (Pederson difficulty index 5-6 score) 5. Operation time must be less or equal to 1 hour 6. An absence of periodontal disease, infection, swelling before surgery 7. Same person to surgery second time greater than or equal to 3 weeks

Exclusion criteria

Exclusion criteria: 1. Taking analgesic medications, such as aspirin, paracetamol, NSAIDs, opioids, or any other agents between 24 hours and 2 weeks before surgery 2. Patients with a history of severe asthma, gastrointestinal disorders such as Dyspepsia or Peptic ulcer(PU)) Bile duct obstruction, hematologic, renal, or hepatic disease; immunosuppressive disorder; neurological disorder affecting pain perception 3. Taking medication (use anticoagulant or antiplatelet, cancer drugs) 4. Pregnancy and Lactation Allergy to Local anesthetic, NSAID(Ibuprofen), curcumin, amoxicillin, tramadol, and paracetamol 5. Smoking

Design outcomes

Primary

Measure	Time frame
Pain score after surgical removal of lower third molar impacted tooth 1, 2, 6,12, 24,48,72 hour and 7 days visual analog scale (VAS) 1-10	—

Secondary

Measure	Time frame
N/A N/A N/A	—

Countries

Thailand

Contacts

Public ContactSettakorn Pongpanich

Prince of Sonkla University

settakorn.p@psu.ac.th0897330434

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026