Acute coronary syndrome ACS Gut microbiota Blood metabolites TMAO LPS Troponin
Conditions
Interventions
The patient had acute myocardial infarction,The patient who had high risk for cardiovascular events.
Diagnostic,Diagnostic
ASC patients,Cardiovascular high risks patients
Sponsors
The faculty of Medicine endowment fund
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Post ACS group 1. Age 18 to 80 years old 2. Diagnosed of acute coronary syndrome (ST-elevation myocardial infarction or non-ST-elevation myocardial infarction) patients receiving coronary angiography or revacularization within 12 to 24 hours at Cardiovascular and Critical Care unit in Maharaj Nakorn Chiang Mai hospital Normal population group 1. Age 18 to 80 years old 2. Healthy volunteer who has age sex and comorbidities matched at Outpatients clinic of Internal medicine department at Maharaj Nakorn Chiang Mai hospital 2.1 Hypertension defined as home BP more than 135 over 85 or on antihypertensive medication 2.2 Diabetes mellitus type 2 defined as HbA1c more than 7 percent or less than 7 percent FBS more than 126 random glucose more than 200 on antidiabetic medication 2.3 Dyslipidemia defined as LDL more than 70 or on anti lipid medication
Exclusion criteria
Exclusion criteria: 1. Cardiac arrest and cannot be recover 2. Life expectancy less than 1 year 3. History of acute cardiovascular events (including acute coronary syndrome, stroke, heart failure, acute/critical limb ischemia) 4. History of heart failure reduced ejection fraction 5. History of antibiotics or probiotics in past 4 weeks before recruitment 6. Active infection within 1 week 7. Severe valvular heart disease 8. Informed consent refusal
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut microbiota species and blood metabolites 3 months species and diversity | — |
Secondary
| Measure | Time frame |
|---|---|
| - Gut and blood microbiota association in individual patients with acute coronary syndrome at 0 and 3 months 3 months not statistical method | — |
Countries
Thailand
Contacts
Public ContactNutnicha Suntornlekha
Faculty of Medicine, Chiang Mai University
Outcome results
None listed