Spontaneous intracerebral hemorrhage patients with systolic blood pressure greater than 180 mmHg without intraventricular hemorrhage or subarachnoid hemorrhage hematoma volume less than 60 ml. onset less than 6 hours Effect of a bolus dose of Nicardipine on blood pressure prior to continuous drip acute phase Spontaneous intracerebral hemorrhage intracerebral hemorrhage blood pressure SBP BP Nicardipine bolus infusion continuous drip nicardipine intravenous compare versus neurological d
Conditions
Interventions
A 1 mg. of Nicardipine intravenous injection prior to Nicardipine infusion ,continuous infusion of Nicardipine as a standard treatment without Nicardipine iv. bolus
Experimental Drug,Active Comparator Drug
Nicardipine iv. bolus ,without Nicardipine iv. bolus
Sponsors
Navamindradhiraj University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Spontaneous intracerebral hemorrhage 2. 18-year-old or more 3. Systolic blood pressure 180 mmHg or more 4. GCS more than 5
Exclusion criteria
Exclusion criteria: 1. pregnancy 2. intraventricular hemorrhage, subarachnoid hemorrhage 3. Hematoma volume greater than 60 milliliters 4. onset more than 6 hours 5. refer in 6. allergic to Nicardipine 7. unobtainable a consent form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure every 5 minutes within 1st hour mmHg, automated blood pressure cuff | — |
Secondary
| Measure | Time frame |
|---|---|
| Neurological deterioration 1 hour since presentation Glasgow coma score; GCS,Nicardipine infusion rate 1 hour since nicardipine infusion initiation mg/h | — |
Countries
Thailand
Contacts
Public ContactAdisak Nithimathachoke
Faculty of Medicine Vajira Hospital, Navamindradhiraj University
Outcome results
None listed