Pain after multilevel lumbar spine surgery Spinal metastasis, Nefopam, post-operative pain, analgesia
Conditions
Interventions
1. NSS 500 ml.
2. 0.5% Bupivacaine 20 ml. with Ketorolac 30 mg.,1. NSS 500 ml.
2. 0.5% Bupivacaine 20 ml. with Ketorolac 30 mg.
3. Nefopam 80 mg. if aged over 65 yrs. Nefopam 40 mg.
Active Comparator Drug,Active Comparator Drug
group 1,group 2
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. had been diagnosed with Spinal metastases undergoing operative by pedicular screw instrumentation more than five-level at Siriraj Hospital 2. Aged over 18 years
Exclusion criteria
Exclusion criteria: 1. History of drug allergy to opioids, gabapentinoid, ketorolac or bupivacaine 2. Estimated glomerular filtration rate <30 ml/min 3. Patients with history of epilepsy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| determine 24-hour morphine consumption 24 hrs. after operative PCA record | — |
Secondary
| Measure | Time frame |
|---|---|
| First time to first IV analgesic after operative report in minute after anesthesia,Mean pain score on 12,24,36,48-hour after operative Visual Analog Scale,Nausea and vomiting on 12,24,36,48-hour postoperative Subjective Examination,Tachycardia 100 times/min on 12,24,36,48-hour postoperative Blood pressure monitor,Side effects of opioids such as Hypotension, Respiratory depression on 12,24,36,48-hour postoperative Blood pressure monitor,Morphine consumption from PCA (Report in the milligram of morphine consumption) on 12,24,36,48 hour postoperative PCA | — |
Countries
Thailand
Contacts
Public ContactSirichai Wilartratsami
Siriraj hospital
Outcome results
None listed