bone metastatic patients bone metastases bone metastatic pain cancer patients
Conditions
Interventions
using photon for stereotactic body radiotherapy for bone metastatic site,using proton for stereotactic body radiotherapy for bone metastatic site
photon SBRT,proton SBRT
Sponsors
Radiation oncology division, Radiology Department, KCMH
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients with a pathologic diagnosis of malignancy 2.Aged older than 18 years old 3.Patients with any radiographic evidence of bone metastases, including plain x-ray, bone scan, CT scan , MRI scan or PET scan 4.Patients with spine and non-spine lesions 5.With pain or dysathesia ( Pain score of at least 2 on the scale) 6.Patients with a life expectancy of more than 3 months 7.Patients with solitary or oligometastatic or bone- only metastatic disease 8.Patients who are able to complete NPRS scores and the questionnaire of Quality of life 9.Patients with no more than 3 separate radiation treatment fields concurrently 10.Patients with surgery for osseous metastases allowed 11.Patients with gross residual disease or high risk for recurrence after surgery 12.Patients with prior conventional beam radiation therapy to the treatment site ( more than 90 days after radiation) 13.Patients with spinal cord compression after decompressive surgery
Exclusion criteria
Exclusion criteria: - Patients with radiosensitive tumor such as malignant melanoma - Patients with a pathologic fracture to the treatment site who needs surgery (spinal instability or neurologic deficit resulting from bony fragments) - Patients with spinal canal compromise >25% - Patients with tumor location within 5 mm of spinal cord or caudal equina - Patients who cannot perform spinal MRI with any reasons such as pacemaker - Patients with chemotherapy within 30 days before SBRT - Patients who have systemic radionuclide delivery within 30 days before SBRT - Patients who have previous SBRT
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain score 3 months 11 point pain score | — |
Secondary
| Measure | Time frame |
|---|---|
| toxicity 3 months CTCAE version 5 | — |
Countries
Thailand
Contacts
Public Contactkitwadee Saksornchai
Faculty of Medicine, Chulalongkorn University
Outcome results
None listed