patients undergoing open appendectomy Intravenous paracetamol, morphine dosage, appendectomy surgery, post-operative pain
Conditions
Interventions
normal saline 100 ml iv drip every 6 hours with a total of 4 dose,paracetamol (15mg/kg total dose no more than 1g)iv drip every six hours with four doses in total.
Placebo Comparator Drug,Experimental Drug
control,paracetamol
Sponsors
Burapha University
Eligibility
Sex/Gender
All
Age
15 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.American Society of Anesthesiologists physical status (ASA) I,II,III 2.spinal anesthesia without opioid was performed 3.able to communicate, use the PCA machine, and rating NRS score 4.no history of drugs allergy to morphine or paracetamol 5.normal AST, ALT and creatinine 6.not pregnant or lactation
Exclusion criteria
Exclusion criteria: 1.opioids was given intraoperative 2.failed spinal anesthesia 3.change the operation 4.other analgesia medication used
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| morphine consumption 4hrs,8hrs,12hrs,24hrs,48hrs total dose (mg) | — |
Secondary
| Measure | Time frame |
|---|---|
| pain score pre-opetative,0hr,4hrs,8hrs,12hrs,24hrs,48hrs Numeric Rating Scale (NRS) ,morphine side effect 4hrs,8hrs,12hrs,24hrs,48hrs PONV score, sedation score,paracetamol side effect 4hrs,8hrs,12hrs,24hrs,48hrs yes, no | — |
Countries
Thailand
Contacts
Public ContactSamonkorn Aniwattakool
Faculty of Medicine, Burapha University
Outcome results
None listed