Female pattern hair loss (severity
Conditions
Interventions
Spironolactone(100mg/day) combined with 3% topical minoxidil solution twice daily,Oral placebo combined with 3% topical minoxidil solution twice daily
Active Comparator Drug,Active Comparator Drug
Spironolactone combination with topical minoxidil,Placebo combination with topical minoxidil
Sponsors
Srinakharinwirot university
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. The patient who is diagnosed with female pattern hair loss (Ludwig grade 1-2) 2. Premenopause 3. Ability to see a doctor by appointment 4. Agree to join in research and sign a consent form 5. Get COVID-19 vaccination at least 2 dose
Exclusion criteria
Exclusion criteria: 1. History of chronic renal disease, hepatic disease, cardiovascular disease, Hypertension, Diabetes Mellitus, cancer and Addison's disease. 2. Family history of breast cancer in first degree relatives. 3. Allergic to spironolactone or minoxidil. 4. The patients who take drugs that caused interaction with spironolactone, for example, ACE inhibitors, angiotensin II antagonists, heparin, low molecular weight heparin, lithium, NSAIDs, digoxin, chloestyramine, narcotic drug, corticosteroids. 5. During pregnancy or breast feeding periods. 6. The patients who don't get contraception. 7. The patients who has at least 1 abnormal serum level of BUN > 20.1 mg/dL, creatinine > 1.17, sodium < 135 mmol/L, potassium > 5.1 mmol/L 8. The patients who had history of using drugs that affect to hair regrowth within 6 months before participating in research study, for example, finasteride, dutasteride, flutamide, cyproterone acetate, spironolactone, minoxidil, cimetidine, diazoxide, cyclosporine, ketoconazole,corticosteroids, chemotherapeutic agents, anticonvulsant ,vasodilators 9. The patients who had history of using topical drugs that affect to hair regrowth within 3 months, for example, minoxidil ,finasteride. 10. The patients who had history of using shampoo or hair serum that affects to hair regrowth within 1 months 11. The patients who had history of other treatments for hair loss within 3 months before participating in research study, for example, low-level laser/light therapy ,platelet-rich plasma. 12. The patients who had history of hair transplantation before participating in research study. 13. The patients who has underlying diseases that can cause hair loss, for example, hypo/hyperthyroidism, anemia, malabsorbtion syndrome ,trichotillomania 14. History of diet control or abnormal eating disorder. 15. History of abnormal scalp disease such as seborrheic dermatitis, Tinea capitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hair density 6 months videodermoscope | — |
Secondary
| Measure | Time frame |
|---|---|
| hair diameter, hair density change, patient satisfaction 6 month videodermoscope, 7-point rating scale, 10 point visual analog scale | — |
Countries
Thailand
Contacts
Public ContactPimpakarn Werachattawatchai
Srinakharinwirot University
Outcome results
None listed