Event rate of CRPS type I in post operative foot and ankle surgery complex regional pain syndrome type I Foot and ankle surgery
Conditions
Interventions
Mecobalamin (500 mcg) 1 tab three times x 50 days
,Placebo 1tab three times x 50 days
Thai applied Traditional Medicine department makes placebos by direct compression with lactose 40%, avicel pH101 2
Experimental Drug,Placebo Comparator Drug
Mecobalamin,placebo
Sponsors
Thammasat University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: All patients having surgery from June 2022 to October 2023 for scheduled foot and ankle surgery by a single senior foot and ankle surgeon Participant understand and consent to the protocol of the trial
Exclusion criteria
Exclusion criteria: Diabetic patients were excluded Previous history of CRPS Pregnancy Allergy to vitamin b 12 History on drug contain of vitamin B 12 History of psychological content of anxio-depression Cognitive impairment affecting pain assessment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| event rate of CRPS type I 12 months univariable and multivariable risk difference regression | — |
Secondary
| Measure | Time frame |
|---|---|
| Factors association with CRPS type I Age Sex Types of anesthesia Types of surgery procedure Tourniquet time Immobilization time Mean non- weight bearing time 12 months percentage,mean or median | — |
Countries
Thailand
Contacts
Public ContactMarut Arunakul
Thammasat University
Outcome results
None listed