Comparative study between the efficacy of Hyaluronic acid Gel and Advanced Platelet-Rich Fibrin in Post Extraction Sockets of Impacted Mandibular Third Molars .

Efficacy of Hyaluronic acid Gel and Advanced Platelet-Rich Fibrin in Post Extraction Sockets of Impacted Mandibular Third Molars . Randomized controlled trial

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20220602008

Enrollment

Registered

2022-06-02

Start date

2021-12-28

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Generally healthy Patients aged more than 18 years old . Hyaluronic acid gel ,A-PRF, Third molars, wisdom teeth, Impacted third molar

Interventions

this material applied into the socket After surgical removal of impacted mandibular third molar before suturing,this material applied into the socket After surgical removal of impacted mandibular thi

Active Comparator Procedure/Surgery,Active Comparator Procedure/Surgery,No Intervention Procedure/Surgery

Hyaluronic acid gel group,Advanced Platelet rich fibrin,control group

Eligibility

Sex/Gender

All

Age

18 Years to 30 Years

Inclusion criteria

Inclusion criteria: 1.Patient aged more than 18 years old. 2. Horizontal and mesio angular impacted lower third molar teeth according to Winter classification that require bone removal from around the impacted teeth. Degree of impaction based on Pell & Gregory category (level A or B, class I or II).

Exclusion criteria

Exclusion criteria: Medically compromised patient: 1-Uncontrolled diabetic. 2-Coagulation disorders. 3-Immune compromised patient. 4-Patient treated with amino bisphosphate which affects bone metabolism. 5-Psychiatric problems. 6-Pregnant women. 7- Any medical condition that affects bone healing. 8- Heavy smokers (more than 20 cigarettes a day). 9.patients with distinct periapical pathology 10.Patients undergoing chemotherapy and radiotherapy

Design outcomes

Primary

Measure	Time frame
Pain, Swelling ,Trismus, Soft tissue healing first ,third and seventh days post operative pain by Visual analog scale, trismus by ruler ,soft tissue healing by Early wound healing	—

Secondary

Measure	Time frame
N/A N/A N/A	—

Countries

Iraq

Contacts

Public ContactDr. Ahmed AL Qaisi

University of Baghdad/ College of Dentistry

thoalfikar.shokr1208a@codental.uobaghdad.edu.iq07516167895

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026