endothelial cell loss in cataract surgery in Fuchs endothelial corneal dystrophy endothelial cell loss in cataract surgery in Fuchs endothelial corneal dystrophy
Conditions
Interventions
post phacoemulsification eye drop : ripasudil,post phacoemulsification eye drop : placebo
Placebo Comparator Drug,Placebo Comparator Drug
ripasudil group,placebo
Sponsors
THE 90TH ANNIVERSARY OF CHULALONGKORN UNIVERSITY FUND ( Ratchadaphiseksomphot Endowment Fund)
Eligibility
Sex/Gender
All
Age
40 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age 40-90 years old 2. Diagnosis of FECD with modified Krachmer grade 1-4 and visual significance cataract with eligible for phacoemulsification with intraocular lens implantation 3. Central endothelial cell count > 1,000 cell/mm2 4. Paracentral endothelial cell count > 1,000 cell/mm2 in all superior /inferior/nasal/temporal quadrant 5. Central corneal thickness < 640 micron 6. Cataract grading: nuclear hardness graded by the Emery-Little classification 1-3 7. Willingness to regular follow-up as appointed
Exclusion criteria
Exclusion criteria: 1. History of severe ocular trauma with lens subluxation 2. Corneal scar 3. History of corneal laser vision correction 4. Use of ripasudil before enrollment in the study 5. Active allergy, infection, inflammation at ocular surface 6. Unstable systemic diseases: uncontrolled HT, uncontrolled DM, stroke, coronary artery disease, cerebrovascular disease, bleeding diathesis 7. History of allergy to ripasudil 8. Phacoemulsification with major intraoperative complication such as large posterior capsular tear or zonule dialysis more than 90 degrees
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| % Endothelial cell loss 6 months after surgery specular microscopy | — |
Secondary
| Measure | Time frame |
|---|---|
| central corneal thickness 6 months after surgery ultrasound pachymetry | — |
Countries
Thailand
Contacts
Public ContactBenjama Keeratidamkerngsakul
Chulalongkorn University
Outcome results
None listed