Comparison between xylocaine spray and oral paracetamol for pain reduction during amniocentesis in second trimester pregnancy

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20220530009

Enrollment

510

Registered

2022-05-30

Start date

2022-04-22

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Comparison between xylocaine spray and oral paracetamol for pain reduction during amniocentesis in second trimester pregnancy Pain Amniocentesis Paracetamol Xylocaine spray

Interventions

After requited participants and record vital signs, before the procedure, the participants were asked to complete the visual analog scale (VAS) to qualify their pre-procedure anxiety and anticipated p

Experimental Drug,Experimental Drug,No Intervention No treatment

Xylocaine spray,Paracetamol,Placebo

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: second trimester pregnant women pregnant women with no gross abnormality found in ultrasound

Exclusion criteria

Exclusion criteria: multigestational pregnancy pregnant women with abnormality found in ultrasound pregnant women with contraindication to amniocentesis : threatened abortion history of xylocaine or paracetamol allergy skin infection on abdominal area pregnant women with psychic problems

Design outcomes

Primary

Measure	Time frame
Xylocaine spray 0,15,30 minute after procedure Visual analog scale	—

Secondary

Measure	Time frame
Maternal anxiety during amniocentesis 0,15,30 minute after procedure Visual analog scale	—

Countries

Thailand

Contacts

Public ContactChanokrak Sriwattanapong

Thammasat University Hospital

Chanokrak.sri@gmail.com0830014642

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026