obesity obesity
Conditions
Interventions
The 75 g oral glucose solution was provided to the participants as a 200 ml solution. The test substances (allulose or aspartame) were prepared by the study sponsor (Rajburi Sugar Co., Ltd.) and were
75g glucose with 14g of allulose,75g glucose with 7g of allulose,75g glucose with 1.65g of aspartame
Sponsors
Rajburi Sugar Co., Ltd.
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria included age between 18-60 years and body mass index (BMI) between 28-35 kg/m2.
Exclusion criteria
Exclusion criteria: Exclusion criteria included weight changes of 5 kg or more within 6 weeks of enrollment, known allergies to food or substances utilized in the study, antibiotic, NSAID, or steroid use within 6 weeks before registration, bariatric surgery, active gastrointestinal disorders such as inflammatory bowel disease and short bowel syndrome, severe hypertension (defined as systolic blood pressure above 180 mmHg and/or diastolic blood pressure above 110 mmHg), severe hypertriglyceridemia (triglyceride levels above 500 mg/dL), diabetes mellitus, pregnancy, lactation, and history of phenylketonuria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postprandial glucose 0, 15, 30, 45, 60, 90, and 120 minutes iAUC & peak | — |
Secondary
| Measure | Time frame |
|---|---|
| insulin, C-peptide, GLP-1, glucagon, and leptin 0, 15, 30, 45, 60, 90, and 120 minutes iAUC & peak,gut microbiome baseline 16S rRNA sequencing | — |
Countries
Thailand
Contacts
Public ContactPornpoj Pramyothin
Mahidol University
Outcome results
None listed