Predicting fluid responsiveness by reverse tidal volume challenge in patients undergoing high-risk surgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20220525002

Enrollment

Registered

2022-05-25

Start date

2022-06-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients older than 18 yr who schedule for high-risk surgery with mechanically ventilated during general anesthesia high-risk surgery during general anesthesia, surgery with mechanically ventilated during general anesthesia, reverse tidal volume challenge, fluid responsiveness, pulse pressure variation

Interventions

Hemodynamic variables (HR, SBP, DBP, MAP, CI, PVV, SVV) and Respiratory variables (Pplat, Crs) will be recorded at tidal volume 8 ml/kg, 6 ml/kg, before volume expansion (immediately after MAP, HR, an

Experimental Device

Predicting fluid responsiveness after Reverse tidal volume challenge

Eligibility

Sex/Gender

All

Age

19 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Adult (age equal to or more than 19 years) patient 2. High-risk surgical procedure (expected operative time more than 2 hours and need an invasive arterial pressure monitoring)

Exclusion criteria

Exclusion criteria: 1. patients with preoperative cardiac arrhythmia, moderate to severe valvular heart disease, preoperative left ventricular ejection fraction <40%, right ventricular dysfunction, intracardiac shunts 2. moderate to severe chronic obstructive pulmonary disease, acute lung injury, coexisting open thorax condition 3. moderate to severe renal or liver disease 4. preoperative need of inotropes and vasopressor 5. severe bradycardia 6. abdominal compartment syndrome 7. pregnancy 8. spontaneous breathing 9. Decline to participate in the study

Design outcomes

Primary

Measure	Time frame
AUROC of PPV change after reverse tidal volume challenge to predict fluid responsiveness within 10-15minute (after fluid challenge) Absolute change of PPV after reverse tidal volume challenge	—

Secondary

Measure	Time frame
sensitivity and specificity of PPV change after reverse tidal volume challenge to predict fluid responsiveness within 10-15minute (after fluid challenge) Absolute change of PPV after reverse tidal volume challenge	—

Countries

Thailand

Contacts

Public ContactSunthiti Morakul

Department of Anesthesiology Faculty of Medicine Ramathibodi Hospital, Mahidol University

sunthiti@hotmail.com66818544179

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026