Dexamethasone and Lidocaine Wound Infiltration for Post-cesarean Analgesia

Dexamethasone and Lidocaine with Adrenaline Wound Infusion for Post-Cesarean Delivery Pfannenstiel Incision Analgesia Comparing with Usual Cesarean Delivery Pfannenstiel Incision : A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20220524002

Enrollment

288

Registered

2022-05-24

Start date

2022-06-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-Cesarean delivery Pfannenstiel incision pain Caesarean delivery Pain Dexamethasone Lidocaine

Interventions

Dexamethasone 16 mg local wound infusion, before subcutaneous suturing,2% lidocaine with adrenaline (1:200,000) 20 ml local wound infusion, before subcutaneous suturing,Usual wound suturing

Experimental Drug,Experimental Drug,No Intervention No treatment

Dexamethasone,Lidocaine with adrenaline,Control

Eligibility

Sex/Gender

Female

Age

20 Years to No maximum

Inclusion criteria

Inclusion criteria: Pregnant women who have indication for Cesarean delivery

Exclusion criteria

Exclusion criteria: 1. Allergic history to dexamethasone, lidocaine, or adrenaline 2. Overt diabetes mellitus, or gestational diabetes mellitus who required insulin therapy 3. Cardiovascular disease, pheochromocytoma, or active hyperthyroidism 4. Active phase of labor 5. COVID-19 infection 6. General anesthesia on Cesarean delivery 7. Cesarean hysterectomy 8. Delayed primary suture

Design outcomes

Primary

Measure	Time frame
Pain score At 2, 4, 6, 12, 18, and 24 hours post-operation Visual Analogue Scale	—

Secondary

Measure	Time frame
Post-operative nausea and vomiting Within 24 hours post-operation Injection of specific symptomatic drugs,Post-operative itching Within 24 hours post-operation Injection of specific symptomatic drugs,Post-operative abdominal bloating Within admission Given of specific symptomatic drugs,Post-operative pain reliver Within 24 hours post-operation Injection of meperidine,Post-operative alternative pain reliver Within 24 hours post-operation Injection of alternative pain reliver drugs, besides meperidine	—

Measure

Time frame

Post-operative nausea and vomiting Within 24 hours post-operation Injection of specific symptomatic drugs,Post-operative itching Within 24 hours post-operation Injection of specific symptomatic drugs,Post-operative abdominal bloating Within admission Given of specific symptomatic drugs,Post-operative pain reliver Within 24 hours post-operation Injection of meperidine,Post-operative alternative pain reliver Within 24 hours post-operation Injection of alternative pain reliver drugs, besides meperidine

—

Countries

Thailand

Contacts

Public ContactRangsiman Smitasiri

Faculty of Medicine, Thammasat University

rangsimanpai@gmail.com0629354159

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026