Cardiovascular autonomic function in chronic obstructive pulmonary disease (COPD) patients with all stages COPD, cardiovascular autonomic function
Conditions
Interventions
COPD patients with autonomic dysfunction based on reference values in Thais.,COPD patients without autonomic dysfunction based on reference values in Thais.,Sex- and age- match control subjects
Screening,Screening,Screening
COPD with autonomic dysfunction,COPD without autonomic dysfunction,Non-COPD
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: COPD patients, all severity (mild, moderate, severe and very severe), as defined by the Global Initiative for Obstructive Lung Disease (GOLD) guidelines (2) with forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) ratio < 0.7 will be recruited if they meet the following criteria: 1) Age between 40-80 years old; 2) Stable conditions, i.e. no acute exacerbation, change in pharmacological therapy, or hospital admission in the past 1 month; 3) Good ability to communicate and follow instructions.
Exclusion criteria
Exclusion criteria: Subjects of either group will be excluded from this study if they meet the following criteria: 1) History of diabetes mellitus, cardiac arrhythmias, lung cancer, or mental disorder; 2) Alcoholism and/or current smoker; 3) Musculoskeletal or neurological abnormalities, such as stroke, upper limb or lower limb injuries; 4) Acute conditions, such as fever, uncontrolled hypertension.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate variability 5 minutes Time-domain parameters: meanNN, SDNN, SDSD, NN50, pNN50, RMSSD,Heart rate variability 5 minutes Frequency-domain parameters: Total power, VLF, or the very low frequency component, LF, or the low frequency component, HF, or the high frequency component, LFnu, HFnu, LF/HF ratio,Blood pressure variability 5 minutes Time-domain parameters: meanBP, SD, SDSD, CV,Blood pressure variability 5 minutes Frequency-domain parameters: Total power, VLF, or the very low frequency component, LF, or the low frequency component, HF, or the high frequency component, LFnu, HFnu,Baroreflex sensitivity 5 minutes Sequence method,Ewing test 5 - 10 minutes for each test Heart rate response to standing, Blood pressure response to standing, Heart rate response to deep breathing, Heart rate response to Valsalva maneuver, Blood pressure response to handgrip exercise,Arterial stiffness Baseline measurement Ankle brachial index,Thai Innate body elements Baseline measurement Earth element, Water element, Wind element, Fire elements | — |
Secondary
| Measure | Time frame |
|---|---|
| Metabolomic profile After the end of autonomic function tests Metabolomic analysis | — |
Countries
Thailand
Contacts
Public ContactAssociate Professor Dr. Wattana Watanapa
Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed